Viral Hemorrhagic Fever (VHF) infections encompass a group of illnesses that affect multiple organ systems and induce vascular damage as well as impaired homeostatic regulation. VHFs can be asymptomatic, but they can also induce high rates of mortality. Unfortunately, the host response mechanisms that determine the pathogenicity, morbidity and mortality of VHFs are poorly understood.
HotRes Database aims to provide centralized access to gene expression data sets from studies of Ebola virus, Marburg virus and Lassa virus infections in non-human primates. These studies were conducted at the US Army Medical Research Institute of Infectious Diseases (USAMRIID), Integrated Research Facilities (IRF) in Fredrick, MD or IRF at the Rocky Mountain Labs (RML). These studies were analyzed at the Connor laboratory at Boston University Medical Center and should aid in the generation of hypotheses and the elucidation of VHF host response mechanisms. Please read more about the Connor lab here.
HoTRes Database was developed by Jonathan Lo, Jose Negron and Deric Zhang at Boston University in partial fulfillment of the requirements for BF768 Biological Database Analysis (Spring 2016) under the instruction of Dr. G. Benson. Further advising was provided by Dr. John Connor and Emily Speranza at BUMC.